Digital and data-driven innovations, applications, and platforms are promising to overcome long-standing market and policy failures and accelerate the transformation of the agriculture and food system. This virtual knowledge exchange is intended to provide informative examples and discussion regarding innovative solutions, business models, and approaches in Data-driven Digital Agriculture. The information presented and examples highlighted are aimed to help policymakers and practitioners consider how they can assess Agriculture and Food Systems project options and adopt decisions tailored to their country’s circumstances and needs.